Article
MAPK-dependent phosphorylation modulates the activity of Suppressor of Hairless in Drosophila.
Cellular signalling - 1 Jan 2015
Auer Jasmin S, Nagel Anja C, Schulz Adriana, Wahl Vanessa, Preiss Anette
Abstract excerpt
Cell differentiation strictly depends on the epidermal growth factor receptor (EGFR)- and Notch-signalling pathways, which are closely intertwined. Here we address the molecular cross talk at the level of Suppressor of Hairless [Su(H)]. The Drosophila transcription factor Su(H) mediates Notch signalling at the DNA level: in the presence of signalling input Su(H) assembles an activator complex on Notch target...
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