Article
Genetic screen for modifiers of the rough eye phenotype resulting from overexpression of the Notch antagonist hairless in Drosophila.
Genesis (New York, N.Y. : 2000) - 1 Jul 2002
Schreiber Simone L, Preiss Anette, Nagel Anja C, Wech Irmgard, Maier Dieter
Abstract excerpt
Hairless was identified as antagonist in the Notch signaling pathway based on genetic interactions. Molecularly, Hairless inhibits Notch target gene activation by directly binding to the Notch signal transducer Su(H). Additional functional domains apart from the Su(H) binding domain, however, suggest additional roles for the Hairless protein. To further our understanding of Hairless functions, we have performed a...
Topics
- A Kinase Anchor Proteins
- Adaptor Proteins, Signal Transducing
- Alleles
- Animals
- Carrier Proteins
- DNA Mutational Analysis
- Drosophila Proteins
- Drosophila melanogaster
- Eye
- Gene Expression Regulation, Developmental
- Genes, Dominant
- In Situ Hybridization