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Article

Suppressor of hairless, the Drosophila homologue of RBP-J kappa, transactivates the neurogenic gene E(spl)m8.

Idengaku zasshi - 1 Aug 1995

Furukawa T, Kobayakawa Y, Tamura K, Kimura K, Kawaichi M, Tanimura T, Honjo T

Abstract excerpt

Suppressor of Hairless[Su(H)], the Drosophila homologue of RBP-J kappa is a novel type of sequence-specific DNA binding protein without known motifs, and highly conserved in various organisms. Su(H) regulates peripheral nervous system (PNS) development. Recently Su(H) was suggested to participate in the Notch-mediated signal transduction pathway. We show here that the Su(H) protein binds to TGTGGGAA sequence...

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PMID: 7546844
DOI: 10.1266/jjg.70.505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppressor of hairless, the Drosophila homologue of RBP-J kappa, transactivates the neurogenic gene E(spl)m8.PMID 7546844Read ↗

The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.Semantic proximity Read ↗

Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development.Semantic proximity Read ↗

Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster.Semantic proximity Read ↗

Enhancer of splitD, a dominant mutation of Drosophila, and its use in the study of functional domains of a helix-loop-helix protein.Semantic proximity Read ↗

Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators.Semantic proximity Read ↗

Genetic characterization of Drosophila RBP-J kappa (suppressor of hairless) as a neurogenic gene in adult PNS development.Semantic proximity Read ↗

Functional dissection of the Drosophila enhancer of split protein, a suppressor of neurogenesis.Semantic proximity Read ↗

Enhancer of split [E(spl)(D)] is a gro-independent, hypermorphic mutation in Drosophila.Semantic proximity Read ↗

The Enhancer of split complex and adjacent genes in the 96F region of Drosophila melanogaster are required for segregation of neural and epidermal progenitor cells.Semantic proximity Read ↗

Zebrafish Her8a is activated by Su(H)-dependent Notch signaling and is essential for the inhibition of neurogenesis.Semantic proximity Read ↗

The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts.Semantic proximity Read ↗

Persistent expression of genes of the enhancer of split complex suppresses neural development in Drosophila.Semantic proximity Read ↗

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