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Article

Dissecting the mechanisms of suppressor of hairless function.

Developmental biology - 15 Nov 2000

Furriols M, Bray S

Abstract excerpt

Suppressor of Hairless [Su(H)] is a DNA-binding protein that is the main intracellular transducer of the Notch signaling pathway in Drosophila. Several different mechanisms have been proposed to account for the activation of Su(H) by Notch. To further investigate how Su(H) activity is regulated we have used misexpression assays with wild-type Su(H) and with modified forms of Su(H) that contained a nuclear...

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Identifiers

PMID: 11071771
DOI: 10.1006/dbio.2000.9923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Dissecting the mechanisms of suppressor of hairless function.PMID 11071771Read ↗

In vivo structure-function analysis of Drosophila Hairless.Semantic proximity Read ↗

Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless.Semantic proximity Read ↗

Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.Semantic proximity Read ↗

Molecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairless.Semantic proximity Read ↗

Gain of function notch phenotypes associated with ectopic expression of the Su(H) C-terminal domain illustrate separability of Notch and hairless-mediated activities.Semantic proximity Read ↗

Complex genetic interactions of novel Suppressor of Hairless alleles deficient in co-repressor binding.Semantic proximity Read ↗

Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors.Semantic proximity Read ↗

Genetic and Molecular Interactions between HΔCT, a Novel Allele of the Notch Antagonist Hairless, and the Histone Chaperone Asf1 in Drosophila melanogaster.Semantic proximity Read ↗

Generation of New Hairless Alleles by Genomic Engineering at the Hairless Locus in Drosophila melanogaster.Semantic proximity Read ↗

Genetic screen for modifiers of the rough eye phenotype resulting from overexpression of the Notch antagonist hairless in Drosophila.Semantic proximity Read ↗

Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless.Semantic proximity Read ↗

The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.Semantic proximity Read ↗

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