Article
The Conserved MAPK Site in E(spl)-M8, an Effector of Drosophila Notch Signaling, Controls Repressor Activity during Eye Development.
PloS one - 1 Jan 2016
Bandyopadhyay Mohna, Bishop Clifton P, Bidwai Ashok P
Abstract excerpt
The specification of patterned R8 photoreceptors at the onset of eye development depends on timely inhibition of Atonal (Ato) by the Enhancer of split (E(spl) repressors. Repression of Ato by E(spl)-M8 requires the kinase CK2 and is inhibited by the phosphatase PP2A. The region targeted by CK2 harbors additional conserved Ser residues, raising the prospect of regulation via multi-site phosphorylation. Here we...
Topics
- Amino Acid Sequence
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Casein Kinase II
- Conserved Sequence
- Drosophila Proteins
- Drosophila melanogaster
- ErbB Receptors
- Eye
- Gene Expression Regulation, Developmental
- Mitogen-Activated Protein Kinases
- Mutation
- Nerve Tissue Proteins