Article
Genetically separable determinants of hair keratin gene expression.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 2000
Schorpp M, Schlake T, Kreamalmeyer D, Allen P M, Boehm T
Abstract excerpt
The nude locus encodes Whn, a transcription factor of the forkhead/winged-helix class. Mutations in Whn cause failure of differentiation of thymic epithelium with a corresponding lack of intrathymic T-cell development; in the skin, differentiation of follicular keratinocytes is disturbed resulting, in the formation of fragile hair shafts. Here, we describe the identification and characterization of a novel nude...
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