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Article

Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless.

PLoS genetics - 1 May 2017

Praxenthaler Heiko, Nagel Anja C, Schulz Adriana, Zimmermann Mirjam, Meier Markus, Schmid Hannes, Preiss Anette, Maier Dieter

Abstract excerpt

Cell fate choices during metazoan development are driven by the highly conserved Notch signalling pathway. Notch receptor activation results in release of the Notch intracellular domain (NICD) that acts as transcriptional co-activator of the DNA-binding protein CSL. In the absence of signal, a repressor complex consisting of CSL bound to co-repressors silences Notch target genes. The Drosophila repressor complex...

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Identifiers

PMID: 28475577
DOI: 10.1371/journal.pgen.1006774
PMCID: PMC5438185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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