Distinct roles of N-glycosylation at different sites of corin in cell membrane targeting and ectodomain shedding.

doi:10.1074/jbc.M114.606442

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Article

Distinct roles of N-glycosylation at different sites of corin in cell membrane targeting and ectodomain shedding.

The Journal of biological chemistry - 16 Jan 2015

Wang Hao, Zhou Tiantian, Peng Jianhao, Xu Ping, Dong Ningzheng, Chen Shenghan, Wu Qingyu

Abstract excerpt

Corin is a membrane-bound protease essential for activating natriuretic peptides and regulating blood pressure. Human corin has 19 predicted N-glycosylation sites in its extracellular domains. It has been shown that N-glycans are required for corin cell surface expression and zymogen activation. It remains unknown, however, how N-glycans at different sites may regulate corin biosynthesis and processing. In this...

Topics

Animals
Atrial Natriuretic Factor
Cell Membrane
Enzyme Precursors
Flow Cytometry
Glycoside Hydrolases
Glycosylation
HEK293 Cells
Humans
Mice
Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Myocytes, Cardiac

Plasmids

Protein Binding

Protein Structure, Tertiary

Serine Endopeptidases

Source

Open in PubMed Open full text

Identifiers

PMID: 25451932
DOI: 10.1074/jbc.M114.606442
PMCID: PMC4340409

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