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Article

Identification of domain structures in the propeptide of corin essential for the processing of proatrial natriuretic peptide.

The Journal of biological chemistry - 13 Aug 2004

Knappe Sabine, Wu Faye, Madlansacay Mary Rose, Wu Qingyu

Abstract excerpt

Corin is a type II transmembrane serine protease and functions as the proatrial natriuretic peptide (pro-ANP) convertase in the heart. In the extracellular region of corin, there are two frizzled-like cysteine-rich domains, eight low density lipoprotein receptor (LDLR) repeats, a macrophage scavenger receptor-like domain, and a trypsin-like protease domain at the C terminus. To examine the functional importance...

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Source

Identifiers

PMID: 15192093
DOI: 10.1074/jbc.M405041200

Genes

LDLR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of domain structures in the propeptide of corin essential for the processing of proatrial natriuretic peptide.PMID 15192093Read ↗

Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin.Semantic proximity Read ↗

Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity.Semantic proximity Read ↗

A common CORIN variant in hypertension reduces corin intracellular trafficking by exposing an inhibitory N-terminus.Semantic proximity Read ↗

Distinct roles of N-glycosylation at different sites of corin in cell membrane targeting and ectodomain shedding.Semantic proximity Read ↗

Functional analysis of corin protein domains required for PCSK6-mediated activation.Semantic proximity Read ↗

PCSK6-mediated corin activation is essential for normal blood pressure.Semantic proximity Read ↗

Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment.Semantic proximity Read ↗

A corin variant identified in hypertensive patients that alters cytoplasmic tail and reduces cell surface expression and activity.Semantic proximity Read ↗

Identification and functional analysis of CORIN variants in hypertensive patients.Semantic proximity Read ↗

Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes.Semantic proximity Read ↗

N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding.Semantic proximity Read ↗

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