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Article

Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin.

The Journal of biological chemistry - 26 Dec 2003

Knappe Sabine, Wu Faye, Masikat Mary Rose, Morser John, Wu Qingyu

Abstract excerpt

Corin is a cardiac transmembrane serine protease. In cell-based studies, corin converted pro-atrial natriuretic peptide (pro-ANP) to mature ANP, suggesting that corin is potentially the pro-ANP convertase. In this study, we evaluated the importance of the transmembrane domain and activation cleavage in human corin. We showed that a soluble corin that consists of only the extracellular domain was capable of...

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Identifiers

PMID: 14559895
DOI: 10.1074/jbc.M309991200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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