Article
Identification and functional analysis of CORIN variants in hypertensive patients.
Human mutation - 1 Dec 2017
Zhang Yue, Zhou Tiantian, Niu Yayan, He Meiling, Wang Can, Liu Meng, Yang Junhua, Zhang Yonghong, Zhou Jianping, Fukuda Koichi, Qin Jun, Dong Ningzheng, Wu Qingyu
Abstract excerpt
Corin is a serine protease that activates atrial natriuretic peptide (ANP). CORIN gene variants have been reported in patients with hypertension. To date, however, the prevalence of CORIN variants in hypertensive patients remains unknown. To understand the prevalence and functional significance of CORIN variants in hypertension, we sequenced CORIN exons in 300 normal and 401 hypertensive individuals in a Chinese...
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