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Article

Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment.

The Journal of biological chemistry - 15 Mar 2013

Dong Ningzheng, Fang Chaodong, Jiang Yizhi, Zhou Tiantian, Liu Meng, Zhou Jianping, Shen Jianzhong, Fukuda Koichi, Qin Jun, Wu Qingyu

Abstract excerpt

Corin is a cardiac transmembrane serine protease that regulates blood pressure by activating natriuretic peptides. Corin variants have been associated with African Americans with hypertension and heart disease. Here, we report a new mutation in exon 12 of the CORIN gene identified in a family of patients with hypertension. The mutation resulted in R539C substitution in the Fz2 (Frizzled-2) domain of the corin...

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Identifiers

PMID: 23372161
DOI: 10.1074/jbc.M112.411512
PMCID: PMC3597824

Genes

CORIN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment.PMID 23372161Read ↗

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PCSK6-mediated corin activation is essential for normal blood pressure.Semantic proximity Read ↗

A common CORIN variant in hypertension reduces corin intracellular trafficking by exposing an inhibitory N-terminus.Semantic proximity Read ↗

Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin.Semantic proximity Read ↗

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Identification of domain structures in the propeptide of corin essential for the processing of proatrial natriuretic peptide.Semantic proximity Read ↗

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Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.Semantic proximity Read ↗

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