Article
A corin variant identified in hypertensive patients that alters cytoplasmic tail and reduces cell surface expression and activity.
Scientific reports - 9 Dec 2014
Zhang Yue, Li Hui, Zhou Jianping, Wang Aili, Yang Junhua, Wang Can, Liu Meng, Zhou Tiantian, Zhu Li, Zhang Yonghong, Dong Ningzheng, Wu Qingyu
Abstract excerpt
Corin is a membrane-bound protease that regulates blood pressure by activating the natriuretic peptides. CORIN variants have been associated with hypertension and heart disease in African Americans. In this study, we conducted targeted exome sequencing and identified an insertion variant, c.102_103insA, in exon 1 of the CORIN gene. Analysis of two independent cohorts showed that the variant was preferentially...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.