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Article

N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding.

eLife - 11 Jun 2018

Wang Hao, Li Shuo, Wang Juejin, Chen Shenghan, Sun Xue-Long, Wu Qingyu

Abstract excerpt

Trypsin-like serine proteases are essential in physiological processes. Studies have shown that N-glycans are important for serine protease expression and secretion, but the underlying mechanisms are poorly understood. Here, we report a common mechanism of N-glycosylation in the protease domains of corin, enteropeptidase and prothrombin in calnexin-mediated glycoprotein folding and extracellular expression. This...

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Identifiers

PMID: 29889025
DOI: 10.7554/eLife.35672
PMCID: PMC6021170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding.PMID 29889025Read ↗

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