Article
N-Glycosylation as a Tool to Study Antithrombin Secretion, Conformation, and Function.
International journal of molecular sciences - 6 Jan 2021
Águila Sonia, Noto Rosina, Luengo-Gil Ginés, Espín Salvador, Bohdan Nataliya, de la Morena-Barrio María Eugenia, Peñas Julia, Rodenas Maria Carmen, Vicente Vicente, Corral Javier, Manno Mauro, Martínez-Martínez Irene
Abstract excerpt
N-linked glycosylation is a crucial post-translational modification involved in protein folding, function, and clearance. N-linked glycosylation is also used therapeutically to enhance the half-lives of many proteins. Antithrombin, a serpin with four potential N-glycosylation sites, plays a pivotal role in hemostasis, wherein its deficiency significantly increases thrombotic risk. In this study, we used the...
Topics
- Antithrombin III
- Antithrombin Proteins
- Circular Dichroism
- Glycosylation
- Humans
- Models, Molecular
- Mutant Proteins
- Mutation
- Protein Conformation
- Protein Processing, Post-Translational
- Thrombosis