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Article

N-Glycosylation as a Tool to Study Antithrombin Secretion, Conformation, and Function.

International journal of molecular sciences - 6 Jan 2021

Águila Sonia, Noto Rosina, Luengo-Gil Ginés, Espín Salvador, Bohdan Nataliya, de la Morena-Barrio María Eugenia, Peñas Julia, Rodenas Maria Carmen, Vicente Vicente, Corral Javier, Manno Mauro, Martínez-Martínez Irene

Abstract excerpt

N-linked glycosylation is a crucial post-translational modification involved in protein folding, function, and clearance. N-linked glycosylation is also used therapeutically to enhance the half-lives of many proteins. Antithrombin, a serpin with four potential N-glycosylation sites, plays a pivotal role in hemostasis, wherein its deficiency significantly increases thrombotic risk. In this study, we used the...

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Identifiers

PMID: 33419227
DOI: 10.3390/ijms22020516
PMCID: PMC7825591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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