Article
Functional analysis of corin protein domains required for PCSK6-mediated activation.
The international journal of biochemistry & cell biology - 1 Jan 2018
Chen Shenghan, Wang Hao, Li Heng, Zhang Yue, Wu Qingyu
Abstract excerpt
Atrial natriuretic peptide (ANP) is a cardiac hormone essential for normal blood pressure and cardiac function. Corin is a transmembrane serine protease that activates ANP. Recently, we identified proprotein convertase subtilisin/kexin-6 (PCSK6), also called PACE4, as the long-sought corin activator. Both corin and PCSK6 are expressed in cardiomyocytes, but corin activation occurs only on the cell surface. It...
Topics
- Amino Acid Substitution
- Animals
- Catalytic Domain
- Cell Line
- Cell Membrane
- Cell-Free System
- Culture Media, Conditioned
- Enzyme Activation
- Gene Deletion
- Humans
- Ionophores