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Article

Functional analysis of corin protein domains required for PCSK6-mediated activation.

The international journal of biochemistry & cell biology - 1 Jan 2018

Chen Shenghan, Wang Hao, Li Heng, Zhang Yue, Wu Qingyu

Abstract excerpt

Atrial natriuretic peptide (ANP) is a cardiac hormone essential for normal blood pressure and cardiac function. Corin is a transmembrane serine protease that activates ANP. Recently, we identified proprotein convertase subtilisin/kexin-6 (PCSK6), also called PACE4, as the long-sought corin activator. Both corin and PCSK6 are expressed in cardiomyocytes, but corin activation occurs only on the cell surface. It...

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Identifiers

PMID: 29180304
DOI: 10.1016/j.biocel.2017.11.010
PMCID: PMC5745258

Genes

PCSK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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