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Article

A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation.

Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2015

Goth Christoffer K, Halim Adnan, Khetarpal Sumeet A, Rader Daniel J, Clausen Henrik, Schjoldager Katrine T-B G

Abstract excerpt

Regulated shedding of the ectodomain of cell membrane proteins by proteases is a common process that releases the extracellular domain from the cell and activates cell signaling. Ectodomain shedding occurs in the immediate extracellular juxtamembrane region, which is also where O-glycosylation is often found and examples of crosstalk between shedding and O-glycosylation have been reported. Here, we systematically...

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Source

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Identifiers

PMID: 26554003
DOI: 10.1073/pnas.1511175112
PMCID: PMC4664366

Genes

ADAM17
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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