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Article

A common CORIN variant in hypertension reduces corin intracellular trafficking by exposing an inhibitory N-terminus.

Biochemical and biophysical research communications - 10 Sept 2020

He Meiling, Zhang Yue, Li Hui, Liu Meng, Dong Ningzheng, Wu Qingyu

Abstract excerpt

Corin is a transmembrane serine protease that activates atrial natriuretic peptide, a cardiac hormone essential for normal blood pressure. Corin is synthesized as a zymogen and activated on the cell surface. In previous studies, we identified a CORIN variant allele with an adenine insertion in the 5'-end of the coding region in ∼5% of hypertensive individuals in a Chinese population. The protein, named insA,...

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PMID: 32828311
DOI: 10.1016/j.bbrc.2020.07.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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