Article
A common CORIN variant in hypertension reduces corin intracellular trafficking by exposing an inhibitory N-terminus.
Biochemical and biophysical research communications - 10 Sept 2020
He Meiling, Zhang Yue, Li Hui, Liu Meng, Dong Ningzheng, Wu Qingyu
Abstract excerpt
Corin is a transmembrane serine protease that activates atrial natriuretic peptide, a cardiac hormone essential for normal blood pressure. Corin is synthesized as a zymogen and activated on the cell surface. In previous studies, we identified a CORIN variant allele with an adenine insertion in the 5'-end of the coding region in ∼5% of hypertensive individuals in a Chinese population. The protein, named insA,...
Topics
- HEK293 Cells
- Humans
- Hypertension
- Mutation
- Protein Domains
- Protein Transport
- Serine Endopeptidases