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Article

Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity.

Circulation research - 29 Aug 2008

Wang Wei, Liao Xudong, Fukuda Koichi, Knappe Sabine, Wu Faye, Dries Daniel L, Qin Jun, Wu Qingyu

Abstract excerpt

Corin is a cardiac serine protease that acts as the pro-atrial natriuretic peptide (ANP) convertase. Recently, 2 single-nucleotide polymorphisms (SNPs) (T555I and Q568P) in the human corin gene have been identified in genetic epidemiological studies. The minor I555/P568 allele, which is more common in African Americans, is associated with hypertension and cardiac hypertrophy. In this study, we examined the effect...

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Source

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Identifiers

PMID: 18669922
DOI: 10.1161/CIRCRESAHA.108.177352
PMCID: PMC2652846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity.PMID 18669922Read ↗

Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment.Semantic proximity Read ↗

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A corin variant identified in hypertensive patients that alters cytoplasmic tail and reduces cell surface expression and activity.Semantic proximity Read ↗

Dysfunctional corin i555(p568) allele is associated with impaired brain natriuretic peptide processing and adverse outcomes in blacks with systolic heart failure: results from the Genetic Risk Assessment in Heart Failure substudy.Semantic proximity Read ↗

A common CORIN variant in hypertension reduces corin intracellular trafficking by exposing an inhibitory N-terminus.Semantic proximity Read ↗

PCSK6-mediated corin activation is essential for normal blood pressure.Semantic proximity Read ↗

Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin.Semantic proximity Read ↗

Identification of domain structures in the propeptide of corin essential for the processing of proatrial natriuretic peptide.Semantic proximity Read ↗

Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.Semantic proximity Read ↗

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