Article
ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma.
Acta neuropathologica - 1 Jan 2015
Reuss David E, Sahm Felix, Schrimpf Daniel, Wiestler Benedikt, Capper David, Koelsche Christian, Schweizer Leonille, Korshunov Andrey, Jones David T W, Hovestadt Volker, Mittelbronn Michel, Schittenhelm Jens, Herold-Mende Christel, Unterberg Andreas, Platten Michael, Weller Michael, Wick Wolfgang, Pfister Stefan M, von Deimling Andreas
Abstract excerpt
Diffuse gliomas are represented in the 2007 WHO classification as astrocytomas, oligoastrocytomas and oligodendrogliomas of grades II and III and glioblastomas WHO grade IV. Molecular data on these tumors have a major impact on prognosis and therapy of the patients. Consequently, the inclusion of molecular parameters in the WHO definition of brain tumors is being planned and has been forwarded as the...
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