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Article

ATRX loss in adult supratentorial diffuse astrocytomas correlates with p53 over expression and IDH1 mutation and predicts better outcome in p53 accumulated patients.

Histology and histopathology - 1 Jan 2016

Shao Li-Wei, Pan Yi, Qi Xue-Ling, Li Yong-Xiao, Ma Xiao-Long, Yi Wei-Ning, Zhang Jing, Zhong Yan-Feng, Chang Qing

Abstract excerpt

BACKGROUND: IDH1/2 mutation, 1p/19q-codeletion and MGMT hypermethylation are well known molecular markers for gliomas. ATRX and p53 alterations are two lineage-specific genetic aberrations in diffuse astrocytic tumors. The aim of the present study is to clarify the significance of ATRX loss and its correlation with p53 overexpression, IDH1/2 mutations, 1p/19q-codeletion and MGMT hypermethylation in supertentorial...

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Source

Identifiers

PMID: 26395639
DOI: 10.14670/HH-11-664

Genes

ATRX
IDH1
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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