Article
Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT.
Acta neuropathologica - 1 Jun 2017
Pekmezci Melike, Rice Terri, Molinaro Annette M, Walsh Kyle M, Decker Paul A, Hansen Helen, Sicotte Hugues, Kollmeyer Thomas M, McCoy Lucie S, Sarkar Gobinda, Perry Arie, Giannini Caterina, Tihan Tarik, Berger Mitchel S, Wiemels Joseph L, Bracci Paige M, Eckel-Passow Jeanette E, Lachance Daniel H, Clarke Jennifer, Taylor Jennie W, Luks Tracy, Wiencke John K, Jenkins Robert B, Wrensch Margaret R
Abstract excerpt
The "integrated diagnosis" for infiltrating gliomas in the 2016 revised World Health Organization (WHO) classification of tumors of the central nervous system requires assessment of the tumor for IDH mutations and 1p/19q codeletion. Since TERT promoter mutations and ATRX alterations have been shown to be associated with prognosis, we analyzed whether these tumor markers provide additional prognostic information...
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