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Article

H3K27me3 immunostaining is diagnostic and prognostic in diffuse gliomas with oligodendroglial or mixed oligoastrocytic morphology.

Virchows Archiv : an international journal of pathology - 1 Nov 2021

Ammendola Serena, Caldonazzi Nicolò, Simbolo Michele, Piredda Maria Liliana, Brunelli Matteo, Poliani Pietro Luigi, Pinna Giampietro, Sala Francesco, Ghimenton Claudio, Scarpa Aldo, Barresi Valeria

Abstract excerpt

Oligodendroglioma is defined by IDH mutation and 1p/19q codeletion. The latter is mutually exclusive to ATRX immunohistochemical loss and has been recently associated with the loss of H3K27me3 immunostaining. We aimed to assess the diagnostic and prognostic value of H3K27me3 immuno-expression in diffuse gliomas with oligodendroglial or mixed oligoastrocytic morphology. H3K27me3 immunostaining was performed in 69...

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PMID: 34165590
DOI: 10.1007/s00428-021-03134-1
PMCID: PMC8572829

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