Article
ATRX mRNA expression combined with IDH1/2 mutational status and Ki-67 expression refines the molecular classification of astrocytic tumors: evidence from the whole transcriptome sequencing of 169 samples samples.
Oncotarget - 15 May 2014
Cai Jinquan, Yang Pei, Zhang Chuanbao, Zhang Wei, Liu Yanwei, Bao Zhaoshi, Liu Xing, Du Wenzhong, Wang Hongjun, Jiang Tao, Jiang Chuanlu
Abstract excerpt
Astrocytic tumors are the most common primary brain tumors in adults. ATRX mutations have been identified in gliomas and are correlated with its loss of expression, which causes alternative lengthening of telomeres (ALT) leading to genomic instability. In this study, we aimed to explore the role...
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