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Article

ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis.

Acta neuropathologica - 1 Sept 2013

Wiestler Benedikt, Capper David, Holland-Letz Tim, Korshunov Andrey, von Deimling Andreas, Pfister Stefan Michael, Platten Michael, Weller Michael, Wick Wolfgang

Abstract excerpt

Mutation/loss of alpha-thalassemia/mental retardation syndrome X-linked (ATRX) expression has been described in anaplastic gliomas. The present study explored the role of ATRX status in the molecular classification of anaplastic gliomas and its impact on survival in the biomarker cohort of the NOA-04 anaplastic glioma trial. Patients (n = 133) of the NOA-04 trial were analyzed for ATRX expression using...

Topics

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Brain Neoplasms
Chromosome Deletion
DNA Helicases
Glioma
Isocitrate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

Tumor Suppressor Proteins

X-linked Nuclear Protein

Source

Identifiers

PMID: 23904111
DOI: 10.1007/s00401-013-1156-z

Genes

ATRX
MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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