Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.

doi:10.1056/NEJMoa1409405

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Article

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.

The New England journal of medicine - 25 Dec 2014

Genovese Giulio, Kähler Anna K, Handsaker Robert E, Lindberg Johan, Rose Samuel A, Bakhoum Samuel F, Chambert Kimberly, Mick Eran, Neale Benjamin M, Fromer Menachem, Purcell Shaun M, Svantesson Oscar, Landén Mikael, Höglund Martin, Lehmann Sören, Gabriel Stacey B, Moran Jennifer L, Lander Eric S, Sullivan Patrick F, Sklar Pamela, Grönberg Henrik, Hultman Christina M, McCarroll Steven A

Abstract excerpt

BACKGROUND: Cancers arise from multiple acquired mutations, which presumably occur over many years. Early stages in cancer development might be present years before cancers become clinically apparent. METHODS: We analyzed data from whole-exome sequencing of DNA in peripheral-blood cells from 12,380 persons, unselected for cancer or hematologic phenotypes. We identified somatic mutations on the basis of unusual...

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PMID: 25426838
DOI: 10.1056/NEJMoa1409405
PMCID: PMC4290021

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ASXL1
TET2

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