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Article

Phylogenetic reconstruction of myeloproliferative neoplasm reveals very early origins and lifelong evolution

2020-11-09

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in cancer-associated genes drive tumour outgrowth. However, the timing of driver mutations and dynamics of clonal expansion that lead to human cancers are largely unknown. We used 448,553 somatic mutations from whole-genome sequencing of 843 clonal haematopoietic colonies to reconstruct the phylogeny of haematopoiesis, from embryogenesis to clinical disease, in 10 patients with myelopr...

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Literature Corpus work
7088f117-4747-5e17-b65b-25992a119da8
DOI
10.1101/2020.11.09.374710
Open publication

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Phylogenetic reconstruction of myeloproliferative neoplasm reveals very early origins and lifelong evolutionDOI 10.1101/2020.11.09.374710
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