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Article

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults.

Nature communications - 22 Aug 2016

Young Andrew L, Challen Grant A, Birmann Brenda M, Druley Todd E

Abstract excerpt

Clonal haematopoiesis is thought to be a rare condition that increases in frequency with age and predisposes individuals to haematological malignancy. Recent studies, utilizing next-generation sequencing (NGS), observed haematopoietic clones in 10% of 70-year olds and rarely in younger individuals. However, these studies could only detect common haematopoietic clones->0.02 variant allele fraction (VAF)-due to the...

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Identifiers

PMID: 27546487
DOI: 10.1038/ncomms12484
PMCID: PMC4996934

Genes

TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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