Article
Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes.
Cell stem cell - 7 Sept 2017
Coombs Catherine C, Zehir Ahmet, Devlin Sean M, Kishtagari Ashwin, Syed Aijazuddin, Jonsson Philip, Hyman David M, Solit David B, Robson Mark E, Baselga José, Arcila Maria E, Ladanyi Marc, Tallman Martin S, Levine Ross L, Berger Michael F
Abstract excerpt
Clonal hematopoiesis (CH), as evidenced by recurrent somatic mutations in leukemia-associated genes, commonly occurs among aging human hematopoietic stem cells. We analyzed deep-coverage, targeted, next-generation sequencing (NGS) data of paired tumor and blood samples from 8,810 individuals to assess the frequency and clinical relevance of CH in patients with non-hematologic malignancies. We identified CH in 25%...
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