Article
Genetic and environmental risks for clonal hematopoiesis and cancer.
The Journal of experimental medicine - 6 Jan 2025
Franco Stephanie, Godley Lucy A
Abstract excerpt
Somatic variants accumulate in all organs with age, with a positive selection of clonal populations that provide a fitness advantage during times of heightened cellular stress leading to clonal expansion. Easily measured within the hematopoietic compartment, clonal hematopoiesis (CH) is now recognized as a common process in which hematopoietic clones with somatic variants associated with hematopoietic neoplasms...
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