Article
Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly.
Blood - 10 Aug 2017
Zink Florian, Stacey Simon N, Norddahl Gudmundur L, Frigge Michael L, Magnusson Olafur T, Jonsdottir Ingileif, Thorgeirsson Thorgeir E, Sigurdsson Asgeir, Gudjonsson Sigurjon A, Gudmundsson Julius, Jonasson Jon G, Tryggvadottir Laufey, Jonsson Thorvaldur, Helgason Agnar, Gylfason Arnaldur, Sulem Patrick, Rafnar Thorunn, Thorsteinsdottir Unnur, Gudbjartsson Daniel F, Masson Gisli, Kong Augustine, Stefansson Kari
Abstract excerpt
Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is derived from a single dominant hematopoietic stem cell lineage. Somatic mutations in candidate driver (CD) genes are thought to be responsible for at least some cases of CH. Using whole-genome sequencing of 11 262 Icelanders, we found 1403 cases of CH by using barcodes of mosaic somatic mutations in peripheral blood, whether...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.