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Article

Comprehensive landscape and interference of clonal haematopoiesis mutations for liquid biopsy: A Chinese pan-cancer cohort.

Journal of cellular and molecular medicine - 1 Nov 2021

Xu Enwu, Su Kai, Zhou Yang, Gong Longlong, Xuan Yiwen, Liao Ming, Cao Jiawang, Li Yaqian, Lu Yujiao, Zhao Yi, Chen Fengxia

Abstract excerpt

Tumour-derived DNA found in the plasma of cancer patients provides the probability to detect somatic mutations from circulating cell-free DNA (cfDNA) in plasma samples. However, clonal hematopoiesis (CH) mutations affect the accuracy of liquid biopsy for cancer diagnosis and treatment. Here, we integrated landscape of CH mutations in 11,725 pan-cancer patients of Chinese and explored effects of CH on liquid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34658138
DOI: 10.1111/jcmm.16966
PMCID: PMC8572768

Genes

TP53
ASXL1
ATM
CHEK2
DNMT3A
SF3B1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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