Age-related clonal hematopoiesis associated with adverse outcomes.

doi:10.1056/NEJMoa1408617

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Age-related clonal hematopoiesis associated with adverse outcomes.

The New England journal of medicine - 25 Dec 2014

Jaiswal Siddhartha, Fontanillas Pierre, Flannick Jason, Manning Alisa, Grauman Peter V, Mar Brenton G, Lindsley R Coleman, Mermel Craig H, Burtt Noel, Chavez Alejandro, Higgins John M, Moltchanov Vladislav, Kuo Frank C, Kluk Michael J, Henderson Brian, Kinnunen Leena, Koistinen Heikki A, Ladenvall Claes, Getz Gad, Correa Adolfo, Banahan Benjamin F, Gabriel Stacey, Kathiresan Sekar, Stringham Heather M, McCarthy Mark I, Boehnke Michael, Tuomilehto Jaakko, Haiman Christopher, Groop Leif, Atzmon Gil, Wilson James G, Neuberg Donna, Altshuler David, Ebert Benjamin L

Abstract excerpt

BACKGROUND: The incidence of hematologic cancers increases with age. These cancers are associated with recurrent somatic mutations in specific genes. We hypothesized that such mutations would be detectable in the blood of some persons who are not known to have hematologic disorders. METHODS: We analyzed whole-exome sequencing data from DNA in the peripheral-blood cells of 17,182 persons who were unselected for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood

Share to Cell Transformation, Neoplastic

Share to Clone Cells

Share to Exome

Share to Hematologic Neoplasms

Share to Hematopoiesis

Share to Hematopoietic Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 25426837
DOI: 10.1056/NEJMoa1408617
PMCID: PMC4306669

Genes

ASXL1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-related clonal hematopoiesis associated with adverse outcomes.PMID 25426837Read ↗

Prevalence, predictors, and outcomes of clonal hematopoiesis in individuals aged ≥80 years.Semantic proximity Read ↗

Genetic and environmental risks for clonal hematopoiesis and cancer.Semantic proximity Read ↗

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.Semantic proximity Read ↗

ASXL1 mutation-related clonal hematopoiesis and age-related diseases: clinical evidence and molecular insightsSemantic proximity Read ↗

Clinical and Therapeutic Implications of Clonal Hematopoiesis.Semantic proximity Read ↗

DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions.Semantic proximity Read ↗

Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly.Semantic proximity Read ↗

Factors associated with clonal hematopoiesis and interaction with marrow environment.Semantic proximity Read ↗

Somatic Mutations and Clonal Hematopoiesis as Drivers of Age-Related Cardiovascular Risk.Semantic proximity Read ↗

Causes of Clonal Hematopoiesis: a Review.Semantic proximity Read ↗

Molecular Pathways in Clonal Hematopoiesis: From the Acquisition of Somatic Mutations to Transformation into Hematologic NeoplasmSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.