Article
Age-related mutations associated with clonal hematopoietic expansion and malignancies.
Nature medicine - 1 Dec 2014
Xie Mingchao, Lu Charles, Wang Jiayin, McLellan Michael D, Johnson Kimberly J, Wendl Michael C, McMichael Joshua F, Schmidt Heather K, Yellapantula Venkata, Miller Christopher A, Ozenberger Bradley A, Welch John S, Link Daniel C, Walter Matthew J, Mardis Elaine R, Dipersio John F, Chen Feng, Wilson Richard K, Ley Timothy J, Ding Li
Abstract excerpt
Several genetic alterations characteristic of leukemia and lymphoma have been detected in the blood of individuals without apparent hematological malignancies. The Cancer Genome Atlas (TCGA) provides a unique resource for comprehensive discovery of mutations and genes in blood that may contribute to the clonal expansion of hematopoietic stem/progenitor cells. Here, we analyzed blood-derived sequence data from...
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