Haplotype defined by the MLH1-93G/A polymorphism is associated with MLH1 promoter hypermethylation in sporadic colorectal cancers.

doi:10.1186/1756-0500-7-835

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Article

Haplotype defined by the MLH1-93G/A polymorphism is associated with MLH1 promoter hypermethylation in sporadic colorectal cancers.

BMC research notes - 24 Nov 2014

Miyakura Yasuyuki, Tahara Makiko, Lefor Alan T, Yasuda Yoshikazu, Sugano Kokichi

Abstract excerpt

BACKGROUND: Methylation of the MLH1 promoter region has been suggested to be a major mechanism of gene inactivation in sporadic microsatellite instability-positive (MSI-H) colorectal cancers (CRCs). Recently, single-nucleotide polymorphism (SNP) in the MLH1 promoter region (MLH1-93G/A; rs1800734) has been proposed to be associated with MLH1 promoter methylation, loss of MLH1 protein expression and MSI-H tumors....

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Identifiers

PMID: 25421847
DOI: 10.1186/1756-0500-7-835
PMCID: PMC4253604

Genes

MLH1

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