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Article

The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer.

Genes, chromosomes & cancer - 1 Oct 2008

Samowitz Wade S, Curtin Karen, Wolff Roger K, Albertsen Hans, Sweeney Carol, Caan Bette J, Ulrich Cornelia M, Potter John D, Slattery Martha L

Abstract excerpt

The MLH1 -93 G>A promoter polymorphism has been reported to be associated with an increased risk of microsatellite unstable colorectal cancer. Other than microsatellite instability, however, the genetic and most epigenetic changes of tumors associated with this polymorphism have not been studied. We evaluated associations between the -93 G>A polymorphism and CpG island methylator phenotype (CIMP), BRAF V600E...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to DNA, Neoplasm

Share to Epigenesis, Genetic

Share to Microsatellite Instability

Share to MutL Protein Homolog 1

Share to Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 18615680
DOI: 10.1002/gcc.20584
PMCID: PMC2572137

Genes

MLH1
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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