Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2011

Wong Justin J-L, Hawkins Nicholas J, Ward Robyn L, Hitchins Megan P

Abstract excerpt

Epigenetic silencing of cancer-related genes by promoter methylation is a frequent event in sporadic colorectal cancer. The CpG island methylator phenotype (CIMP+), in which discrete genes throughout the genome are simultaneously methylated, and long-range epigenetic silencing, whereby multiple genes within contiguous chromosomal regions are methylated, have been described in subsets of colorectal cancer. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Adenocarcinoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 3

Share to CpG Islands

Share to DNA Methylation

Share to Gene Silencing

Share to MutL Protein Homolog 1

Share to Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 21102416
DOI: 10.1038/modpathol.2010.212

Genes

MLH1
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer.PMID 21102416Read ↗

Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer.Semantic proximity Read ↗

The CpG island methylator phenotype correlates with long-range epigenetic silencing in colorectal cancer.Semantic proximity Read ↗

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.Semantic proximity Read ↗

The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer.Semantic proximity Read ↗

Clinicopathologic Risk Factor Distributions for MLH1 Promoter Region Methylation in CIMP-Positive Tumors.Semantic proximity Read ↗

The dynamic DNA methylation landscape of the mutL homolog 1 shore is altered by MLH1-93G>A polymorphism in normal tissues and colorectal cancer.Semantic proximity Read ↗

Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer.Semantic proximity Read ↗

Aberrant DNA methylation patterns in microsatellite stable human colorectal cancers define a new marker panel for the CpG island methylator phenotype.Semantic proximity Read ↗

Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases.Semantic proximity Read ↗

Microsatellite instability and MLH1 promoter hypermethylation in colorectal cancerSemantic proximity Read ↗

Epidemiological, clinical and molecular characterization of Lynch‐like syndrome: A population‐based studySemantic proximity Read ↗

Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.