Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MLH1 promoter germline-methylation in selected probands of Chinese hereditary non-polyposis colorectal cancer families.

World journal of gastroenterology - 28 Dec 2008

Zhou Heng-Hua, Yan Shi-Yan, Zhou Xiao-Yan, Du Xiang, Zhang Tai-Ming, Cai Xu, Lu Yong-Ming, Cai San-Jun, Shi Da-Ren

Abstract excerpt

AIM: To detect the MLH1 gene promoter germline-methylation in probands of Chinese hereditary nonpolyposis colorectal cancer (HNPCC), and to evaluate the role of methylation in MLH1 gene promoter and molecular genetics in screening for HNPCC. METHODS: The promoter germline methylation of MLH1 gene was detected by methylation-specific PCR (MSP) in 18 probands from unrelated HNPCC families with high...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Germ-Line Mutation

Share to Microsatellite Instability

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Share to Nuclear Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19109866
DOI: 10.3748/wjg.14.7329
PMCID: PMC2778116

Genes

MLH1
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MLH1 promoter germline-methylation in selected probands of Chinese hereditary non-polyposis colorectal cancer families.PMID 19109866Read ↗

Efficient molecular screening of Lynch syndrome by specific 3' promoter methylation of the MLH1 or BRAF mutation in colorectal cancer with high-frequency microsatellite instability.Semantic proximity Read ↗

Genetic diagnosis strategy of hereditary non-polyposis colorectal cancer.Semantic proximity Read ↗

Distinct mutations in MLH1 and MSH2 genes in hereditary non-polyposis colorectal cancer (HNPCC) families from China.Semantic proximity Read ↗

MLH1 promoter methylation frequency in colorectal cancer patients and related clinicopathological and molecular features.Semantic proximity Read ↗

Testing region selection and prognostic analysis of MLH1 promoter methylation in colorectal cancer in ChinaSemantic proximity Read ↗

Densely methylated MLH1 promoter correlates with decreased mRNA expression in sporadic colorectal cancers.Semantic proximity Read ↗

MLH1 Promoter Methylation Could Be the Second Hit in Lynch Syndrome Carcinogenesis.Semantic proximity Read ↗

Three novel missense germline mutations in different exons of MSH6 gene in Chinese hereditary non-polyposis colorectal cancer families.Semantic proximity Read ↗

A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor.Semantic proximity Read ↗

Lynch syndrome-associated endometrial carcinoma with MLH1 germline mutation and MLH1 promoter hypermethylation: a case report and literature reviewSemantic proximity Read ↗

Amplicon-based NGS test for assessing MLH1 promoter methylation and its correlation with BRAF mutation in colorectal cancer patients.Semantic proximity Read ↗

Selection of patients with germline MLH1 mutated Lynch syndrome by determination of MLH1 methylation and BRAF mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.