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Article

Densely methylated MLH1 promoter correlates with decreased mRNA expression in sporadic colorectal cancers.

Genes, chromosomes & cancer - 1 Sept 2002

Furukawa Taiji, Konishi Fumio, Masubuchi Shigehiko, Shitoh Kazuhisa, Nagai Hideo, Tsukamoto Toshihiko

Abstract excerpt

It has been reported that MLH1 is silenced by promoter methylation, and that this phenomenon is associated with microsatellite instability (MSI) in sporadic colorectal cancer (CRC). To clarify the significance of MLH1 promoter methylation in sporadic CRC, we examined the correlation between methylation status over the entire promoter region and mRNA expression in cases showing high-frequency MSI (MSI-H). MLH1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12203784
DOI: 10.1002/gcc.10100

Genes

MLH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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