Article
MLH1-93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation.
BMC cancer - 5 Jan 2018
Fennell Lochlan J, Jamieson Saara, McKeone Diane, Corish Tracie, Rohdmann Megan, Furner Tori, Bettington Mark, Liu Cheng, Kawamata Futoshi, Bond Catherine, Van De Pols Jolieke, Leggett Barbara, Whitehall Vicki
Abstract excerpt
BACKGROUND: Sessile serrated adenomas with BRAF mutation progress rapidly to cancer following the development of dysplasia (SSAD). Approximately 75% of SSADs methylate the mismatch repair gene MLH1, develop mismatch repair deficiency and the resultant cancers have a good prognosis. The remaining SSADs and BRAF mutant traditional serrated adenomas (TSA) develop into microsatellite stable cancers with a poor...
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