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Article

Evidence for heritable predisposition to epigenetic silencing of MLH1.

International journal of cancer - 15 Apr 2007

Chen Huiping, Taylor Nicholas P, Sotamaa Kaisa M, Mutch David G, Powell Matthew A, Schmidt Amy P, Feng Sheng, Hampel Heather L, de la Chapelle Albert, Goodfellow Paul J

Abstract excerpt

Epigenetic silencing of MLH1 is the most common cause of defective DNA mismatch repair in endometrial and colorectal cancers. We hypothesized that variation in the MLH1 gene might contribute to the risk for MLH1 methylation and epigenetic silencing. We undertook a case-control study to test for the association between MLH1 variants and abnormal MLH1 methylation. Eight MLH1 SNPs were typed in the normal DNA from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17230510
DOI: 10.1002/ijc.22406

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evidence for heritable predisposition to epigenetic silencing of MLH1.PMID 17230510Read ↗

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The MLH1 c.-27C>A and c.85G>T variants are linked to dominantly inherited MLH1 epimutation and are borne on a European ancestral haplotype.Semantic proximity Read ↗

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MLH1/PMS2-deficient Endometrial Carcinomas in a Universally Screened Population: MLH1 Hypermethylation and Germline Mutation StatusSemantic proximity Read ↗

Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.Semantic proximity Read ↗

Endometrial cancer risk is associated with variants of the mismatch repair genes MLH1 and MSH2.Semantic proximity Read ↗

The association between MLH1 -93 G>A polymorphism of DNA mismatch repair and cancer susceptibility: a meta-analysis.Semantic proximity Read ↗

Haplotype defined by the MLH1-93G/A polymorphism is associated with MLH1 promoter hypermethylation in sporadic colorectal cancers.Semantic proximity Read ↗

Mechanisms of inactivation of MLH1 in hereditary nonpolyposis colorectal carcinoma: a novel approach.Semantic proximity Read ↗

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