Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Incidence of -93 MLH1 promoter polymorphism in familial and sporadic colorectal cancer.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland - 1 Mar 2013

Martínez-Urueña N, Macías L, Pérez-Cabornero L, Infante M, Lastra E, Cruz J J, Miner C, González R, Durán M

Abstract excerpt

AIM: The MLH1 promoter contains a common single nucleotide polymorphism (-93 guanine > adenine) located in an essential region for maximum transcriptional activity. This has been associated with an increased risk of microsatellite instability (MSI) colorectal cancer. The aim of the study was to c...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to DNA Repair

Share to Incidence

Share to Microsatellite Instability

Share to MutL Protein Homolog 1

Source

Identifiers

PMID: 23374646
DOI: 10.1111/codi.12112

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23374646-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Incidence of -93 MLH1 promoter polymorphism in familial and sporadic colorectal cancer.PMID 23374646Read ↗

MLH1 -93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer.Semantic proximity Read ↗

Association between MLH1 -93G>a polymorphism and risk of colorectal cancer.Semantic proximity Read ↗

Haplotype defined by the MLH1-93G/A polymorphism is associated with MLH1 promoter hypermethylation in sporadic colorectal cancers.Semantic proximity Read ↗

MLH1-93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation.Semantic proximity Read ↗

MLH1-93G > A is a risk factor for MSI colorectal cancer.Semantic proximity Read ↗

The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer.Semantic proximity Read ↗

Contribution of the MLH1 -93G>a promoter polymorphism in modulating susceptibility risk in Malaysian colorectal cancer patients.Semantic proximity Read ↗

MLH1 -93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer.Semantic proximity Read ↗

Effect of MLH1 -93G>A on gene expression in patients with colorectal cancer.Semantic proximity Read ↗

Ovarian cancer risk is associated with a common variant in the promoter sequence of the mismatch repair gene MLH1.Semantic proximity Read ↗

MLH1 rs1800734 Pathogenic Variant among Patients with Colorectal Cancer in the Lower Northeastern Region of Thailand.Semantic proximity Read ↗

Functional effects of the MLH1-93G>A polymorphism on MLH1/EPM2AIP1 promoter activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.