Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity

17 Jul 2025

Abstract excerpt

DNMT3A is a critical regulator of hematopoietic stem cell (HSC) fate decisions and the most recurrently mutated gene in human clonal hematopoiesis (CH). DNMT3A is described as a DNA methyltransferase enzyme, but cells with DNMT3A loss of function show minor changes in DNA methylation that do not correlate with altered gene expression. To explore the possibility that Dnmt3a has DNA-methylation-independent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40680747
DOI: 10.1016/j.stem.2025.06.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrityPMID 40680747Read ↗

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In VivoSemantic proximity Read ↗

Dnmt3a is essential for hematopoietic stem cell differentiation.Semantic proximity Read ↗

Dnmt3a Is Essential for Hematopoietic Stem Cell DifferentiationSemantic proximity Read ↗

Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformationSemantic proximity Read ↗

Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation.Semantic proximity Read ↗

Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.Semantic proximity Read ↗

Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies.Semantic proximity Read ↗

DNA methyltransferases in hematologic malignancies.Semantic proximity Read ↗

Remethylation of Dnmt3a-/- hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing.Semantic proximity Read ↗

DNMT3A haploinsufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells.Semantic proximity Read ↗

Alterations to DNMT3A in Hematologic Malignancies.Semantic proximity Read ↗

Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal HaematopoiesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.