Article
DNMT3A in haematological malignancies.
Nature reviews. Cancer - 1 Mar 2015
Yang Liubin, Rau Rachel, Goodell Margaret A
Abstract excerpt
DNA methylation patterns are disrupted in various malignancies, suggesting a role in the development of cancer, but genetic aberrations directly linking the DNA methylation machinery to malignancies were rarely observed, so this association remained largely correlative. Recently, however, mutations in the gene encoding DNA methyltransferase 3A (DNMT3A) were reported in patients with acute myeloid leukaemia (AML),...
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