Article
Differences in regulation of Drosophila and vertebrate integrin affinity by talin.
Molecular biology of the cell - 1 Aug 2008
Helsten Teresa L, Bunch Thomas A, Kato Hisashi, Yamanouchi Jun, Choi Sharon H, Jannuzi Alison L, Féral Chloe C, Ginsberg Mark H, Brower Danny L, Shattil Sanford J
Abstract excerpt
Integrin-mediated cell adhesion is essential for development of multicellular organisms. In worms, flies, and vertebrates, talin forms a physical link between integrin cytoplasmic domains and the actin cytoskeleton. Loss of either integrins or talin leads to similar phenotypes. In vertebrates, talin is also a key regulator of integrin affinity. We used a ligand-mimetic Fab fragment, TWOW-1, to assess talin's role...
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