Article
Differences in regulation of Drosophila and vertebrate integrin affinity by talin.
Molecular biology of the cell - 1 Aug 2008
Helsten Teresa L, Bunch Thomas A, Kato Hisashi, Yamanouchi Jun, Choi Sharon H, Jannuzi Alison L, Féral Chloe C, Ginsberg Mark H, Brower Danny L, Shattil Sanford J
Abstract excerpt
Integrin-mediated cell adhesion is essential for development of multicellular organisms. In worms, flies, and vertebrates, talin forms a physical link between integrin cytoplasmic domains and the actin cytoskeleton. Loss of either integrins or talin leads to similar phenotypes. In vertebrates, talin is also a key regulator of integrin affinity. We used a ligand-mimetic Fab fragment, TWOW-1, to assess talin's role...
Topics
- Animals
- CHO Cells
- Cricetinae
- Cricetulus
- Cytoplasm
- Drosophila
- Flow Cytometry
- Gene Expression Regulation
- Integrins
- Models, Biological
- Phenotype