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Article

The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link.

Nature cell biology - 1 Apr 2008

Löer Birgit, Bauer Reinhard, Bornheim Roland, Grell Jessica, Kremmer Elisabeth, Kolanus Waldemar, Hoch Michael

Abstract excerpt

Integrin transmembrane receptors mediate cell adhesion through intracellular linker proteins that connect to the cytoskeleton. Of the numerous linker proteins identified, only a few, including Talin and Integrin-linked-kinase (ILK), are essential and evolutionarily conserved. The wech gene encodes a newly discovered and highly conserved regulator of integrin-mediated adhesion in Drosophila melanogaster. Embryos...

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Source

Identifiers

PMID: 18327251
DOI: 10.1038/ncb1704

Genes

ILK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link.PMID 18327251Read ↗

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Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane.Semantic proximity Read ↗

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