Article
Tensin stabilizes integrin adhesive contacts in Drosophila.
Developmental cell - 1 Mar 2004
Torgler Catherine N, Narasimha Maithreyi, Knox Andrea L, Zervas Christos G, Vernon Matthew C, Brown Nicholas H
Abstract excerpt
We report the functional characterization of the Drosophila ortholog of tensin, a protein implicated in linking integrins to the cytoskeleton and signaling pathways. A tensin null was generated and is viable with wing blisters, a phenotype characteristic of loss of integrin adhesion. In tensin mutants, mechanical abrasion is required during wing expansion to cause wing blisters, suggesting that tensin strengthens...
Topics
- Animals
- Animals, Genetically Modified
- Cell Adhesion
- Cytoskeleton
- Drosophila
- Embryo, Nonmammalian
- Focal Adhesion Protein-Tyrosine Kinases
- Gene Expression
- Gene Expression Regulation, Developmental
- Genes, Insect