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Article

The actin binding sites of talin have both distinct and complementary roles in cell-ECM adhesion.

PLoS genetics - 1 Apr 2024

Camp Darius, Venkatesh Bhavya, Solianova Veronika, Varela Lorena, Goult Benjamin T, Tanentzapf Guy

Abstract excerpt

Cell adhesion requires linkage of transmembrane receptors to the cytoskeleton through intermediary linker proteins. Integrin-based adhesion to the extracellular matrix (ECM) involves large adhesion complexes that contain multiple cytoskeletal adapters that connect to the actin cytoskeleton. Many of these adapters, including the essential cytoskeletal linker Talin, have been shown to contain multiple actin-binding...

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Identifiers

PMID: 38662776
DOI: 10.1371/journal.pgen.1011224
PMCID: PMC11075885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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