Article
Multiple factors contribute to integrin-talin interactions in vivo.
Journal of cell science - 15 Apr 2006
Tanentzapf Guy, Martin-Bermudo Maria D, Hicks Marcus S, Brown Nicholas H
Abstract excerpt
The cytoplasmic protein talin is an essential part of the integrin-cytoskeleton link. We characterized the interaction between integrin and two conserved regions of talin, the N-terminal ;head' domain and the C-terminus, which includes the I/LWEQ domain, within the living organism. Green-fluorescent-protein-tagged head and C-terminal domains were recruited to integrin adhesion sites. Both required integrins for...
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