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Article

Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling.

British journal of clinical pharmacology - 1 Sept 2014

Størset Elisabet, Holford Nick, Hennig Stefanie, Bergmann Troels K, Bergan Stein, Bremer Sara, Åsberg Anders, Midtvedt Karsten, Staatz Christine E

Abstract excerpt

AIMS: The aim was to develop a theory-based population pharmacokinetic model of tacrolimus in adult kidney transplant recipients and to externally evaluate this model and two previous empirical models. METHODS: Data were obtained from 242 patients with 3100 tacrolimus whole blood concentrations. External evaluation was performed by examining model predictive performance using Bayesian forecasting. RESULTS:...

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Identifiers

PMID: 25279405
DOI: 10.1111/bcp.12361
PMCID: PMC4243902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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